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Oxidative stress, which results from the imbalance between the production and neutralization of ROS, is also reported to be involved in a large number of pathological states, such as Alzheimers disease [30], Parkinsons disease [31], atherosclerosis [32], heart failure [33], myocardial infarction [34], and hepatic encephalopathy [35]

In summary, reduction of roGFP2 WT (S 2 ) as a model non-glutathione protein disulfide substrate requires the presence of GSH and PfGrx

IV (Intravenous) Glutathione: Delivered directly into the bloodstream at clinics, ensuring 100% absorption

Statements Author contributions MEHK: Conceptualization, Writing original draft, Writing review and editing